Diagnostic utility of enzyme-linked immunospot assay for interferon-γ in a patient with tuberculous arthritis and pyomyositis

Diagnostic utility of enzyme-linked immunospot assay for interferon-γ in a patient with tuberculous arthritis and pyomyositis.

The indolent and nonspecific presentations of tuberculous arthritis and pyomyositis render their diagnosis a great challenge for clinicians. We describe a 78-year-old man with swelling and pain of right knee for 6 months. The patient was empirically treated for tuberculosis because positive enzyme-linked immunospot assay for interferon-γ of blood was reported at 2 days after aspiration of synov...

Diagnostic Utility of Interferon-γ Release Assay in Tuberculous Lymphadenitis

Interferon-γ Enzyme-Linked Immunospot Assay in Patients with Tuberculosis and Healthy Adults

BACKGROUND Interferon-γ assays based on tuberculosis (TB)-specific antigens have been utilized for diagnosing and ruling out latent TB and active TB, but their utility is still limited for TB incidence countries. The aim of this study is to understand the clinical utility of enzyme-linked immunospot (ELISpot) assays among patients with clinically suspected TB and healthy adults in clinical prac...

Diagnosis of Tuberculosis by an Enzyme-Linked Immunospot Assay for Interferon-γ

We evaluated an enzyme-linked immunospot assay for interferon-gamma (T SPOT-TB) for rapid diagnosis of active tuberculosis (TB) in a disease-endemic area. From January to June 2005, patients whose clinical symptoms and radiographic findings were compatible with TB were recruited, and a blood sample was obtained for T SPOT-TB assay within 7 days of microbiologic studies. Sixty-five patients were...

Diagnostic potential of an enzyme-linked immunospot assay in tuberculous pericarditis.

Tuberculous pericarditis is a rare disease in developed countries. The diagnosis is difficult to set since there are no robust rapid tests, and culture of pericardial fluid for Mycobacterium tuberculosis is often negative. T-SPOT.TB, an enzyme-linked immunospot (ELISPOT) test, measures the gamma interferon response of lymphocytes against tuberculosis antigens and can be performed on blood and b...